\documentclass[12pt]{book}
\usepackage{geometry}                % See geometry.pdf to learn the layout options. There are lots.
\geometry{letterpaper}                   % ... or a4paper or a5paper or ... 
\usepackage{graphicx}
\usepackage{amssymb}

\usepackage{fontspec,xltxtra,xunicode}
\defaultfontfeatures{Mapping=tex-text}
\setromanfont[Mapping=tex-text]{Hoefler Text}
\setsansfont[Scale=MatchLowercase,Mapping=tex-text]{Gill Sans}
\setmonofont[Scale=MatchLowercase]{Andale Mono}

\title{Brief Article}
\author{The Author}

\begin{document}
\newfontfamily{\H}[Scale=1.2]{Hei}
\newfontfamily{\S}[Scale=1.2]{宋体}
\newfontfamily{\K}{Kai}
\newfontfamily{\F}{仿宋_GB2312}
\newfontfamily{\Y}{微软雅黑}
\LARGE {\Y 驻玻利维亚使馆办案手册}\\

\chapter{\H 标题一}

\section{\S 标题一}

\paragraph*{\K 这里可以输入正文}
\paragraph*{\Y 这里可以输入正文}

\subsection{\F 小标题一}



\end{document}  